Article
The Role of PIEZO2 in Human Mechanosensation.
The New England journal of medicine - 6 Oct 2016
Chesler Alexander T, Szczot Marcin, Bharucha-Goebel Diana, Čeko Marta, Donkervoort Sandra, Laubacher Claire, Hayes Leslie H, Alter Katharine, Zampieri Cristiane, Stanley Christopher, Innes A Micheil, Mah Jean K, Grosmann Carla M, Bradley Nathaniel, Nguyen David, Foley A Reghan, Le Pichon Claire E, Bönnemann Carsten G
Abstract excerpt
BACKGROUND: The senses of touch and proprioception evoke a range of perceptions and rely on the ability to detect and transduce mechanical force. The molecular and neural mechanisms underlying these sensory functions remain poorly defined. The stretch-gated ion channel PIEZO2 has been shown to be essential for aspects of mechanosensation in model organisms. METHODS: We performed whole-exome sequencing analysis in...
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