Article

Multiplexed high-throughput immune cell imaging reveals molecular health-associated phenotypes

2021-12-04

Abstract excerpt

<h4>Summary</h4> Phenotypic plasticity is essential to the immune system, yet the factors that shape it are not fully understood. Here, we comprehensively analyze immune cell phenotypes including morphology across human cohorts by single-round multiplexed immunofluorescence, automated microscopy, and deep learning. Using the uncertainty of convolutional neural networks to cluster the phenotypes of 8 distinct immu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 475879c6-7bed-5f61-b99d-c168d9cc58b0
DOI: 10.1101/2021.12.03.471105

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multiplexed high-throughput immune cell imaging reveals molecular health-associated phenotypesDOI 10.1101/2021.12.03.471105Read

Multiplexed high-throughput immune cell imaging reveals molecular health-associated phenotypes.Semantic proximity Read

Image-based profiling of healthy donor immune cells with Blood Cell Painting reveals novel genotype-phenotype associationsSemantic proximity Read

The 10,000 Immunomes Project: A resource for human immunologySemantic proximity Read

3-D deconvolution of human skin immune architecture with Multiplex Annotated Tissue Imaging System (MANTIS)Semantic proximity Read

Deep learning representations of human Immune Health for precision immunologySemantic proximity Read

Cross-tissue immune cell analysis reveals tissue-specific adaptations and clonal architecture in humansSemantic proximity Read

From Cellular Characteristics to Disease Diagnosis: Uncovering Phenotypes with SupercellsSemantic proximity Read

Standardized high-dimensional spectral cytometry protocol and panels for whole blood immune phenotyping in clinical and translational studies.Semantic proximity Read

Machine Learning Identifies Signatures of Macrophage Reactivity and Tolerance that Predict Disease OutcomesSemantic proximity Read

High-dimensional spectral cytometry panels for whole blood immune phenotypingSemantic proximity Read

Linking histology and molecular state across human tissuesSemantic proximity Read

50-color phenotyping of the human immune system with in-depth assessment of T cells and dendritic cellsSemantic proximity Read