Article

Dual targeting of BCL-XL and MCL-1 exposes a rapid and exploitable apoptotic vulnerability in non-small cell lung cancer

2026-07-10

Abstract excerpt

<title>Abstract</title> <p>Non-small cell lung cancer (NSCLC) is frequently refractory to mitochondrial apoptosis despite oncogenic and therapeutic stress. Although individual anti-apoptotic BCL-2 family members have been implicated in NSCLC survival, it has remained unclear whether this reflects dominant single-protein dependencies or a cooperative pro-survival network. This uncertainty is exacerbated by the hig...

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Literature Corpus work: 473689d2-6862-5e07-beea-d5e2fa40bbc0
DOI: 10.21203/rs.3.rs-8901982/v1

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