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Article

Oncogenic Mutant p53 Sensitizes Non-Small Cell Lung Cancer Cells to Proteasome Inhibition via Oxidative Stress-Dependent Induction of Mitochondrial Apoptosis.

Cancer research communications - 1 Oct 2024

Chougoni Kranthi Kumar, Neely Victoria, Ding Boxiao, Oduah Eziafa, Lam Vianna T, Hu Bin, Koblinski Jennifer E, Windle Bradford E, Palit Deb Swati, Deb Sumitra, Nieva Jorge J, Radhakrishnan Senthil K, Harada Hisashi, Grossman Steven R

Abstract excerpt

SIGNIFICANCE: NSCLC is the leading cause of cancer death due, in part, to a lack of active therapies in advanced disease. We demonstrate that combination therapy with a proteasome inhibitor, BH3-mimetic, and chemotherapy is an active precision therapy in NSCLC cells and tumors expressing Onc-p53 alleles.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39302104
DOI: 10.1158/2767-9764.CRC-23-0637
PMCID: PMC11474859

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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