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Collagen Genes-Related Glomerular Disease.

Advances in kidney disease and health - 1 Jan 2026

Butler Grainne, Quinlan Cathy, Rheault Michelle N

Abstract excerpt

Alport syndrome is a genetic kidney disease caused by variants in genes encoding the ⍺3, ⍺4, or ⍺5 isoforms of type IV collagen leading to hematuria, proteinuria, and CKD in many, but not all, affected patients. Variants in type IV collagen genes have been increasingly recognized and may affect up to 1 in 106 people. There is wide phenotypic variability depending on inheritance pattern (autosomal recessive vs...

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PMID: 42331441
DOI: 10.1053/j.akdh.2026.02.001

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