RNF180 mediates STAT3 activity by regulating the expression of RhoC via the proteasomal pathway in gastric cancer cells

Abstract excerpt

<h4>Background: </h4> Ring finger protein 180 (RNF180) is an important member of the E3 ubiquitin ligase family. As a tumor suppressor gene, RNF180 is significantly associated with the prognosis of patients with gastric cancer (GC) and can inhibit the proliferation, invasion, and migration of GC cells. Signal transducer and activator of transcription 3 (STAT3) is considered one of the most common oncogenes in huma...

Topics

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• Cancer Mechanisms and Therapy
• Cancer-related Molecular Pathways
• Cytokine Signaling Pathways and Interactions
• Histone Deacetylase Inhibitors Research
• interferon and immune responses
• MicroRNA in disease regulation
• Protein Degradation and Inhibitors
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

4713af7d-ac14-5a07-a7cb-bb17a4065896

DOI

10.21203/rs.3.rs-21786/v1