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Article

SPG11 models reveal lysosomal calcium regulation of neural progenitor proliferation.

Neurobiology of disease - 1 Jul 2026

Samaroo Dominic, Cauhapé Margaux, Bernachot Léa, Moulière Salomé, Darios Frédéric

Abstract excerpt

Lysosome dysfunction has been widely implicated in many models of neurodegeneration, but much less is understood of its involvement during brain development in health and disease. Hereditary spastic paraplegia caused by mutations in the SPG11 gene is a neurodegenerative disorder characterized by lysosome dysfunction, which also presents neurodevelopmental alterations. Using knockout mouse and cortical organoid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42049147
DOI: 10.1016/j.nbd.2026.107423

Genes

SPG11
PI4K2A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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