Article

<i>Cdon</i> mutation and fetal alcohol converge on Nodal signaling in a mouse model of holoprosencephaly

2020-05-01

Abstract excerpt

Holoprosencephaly (HPE), a defect in midline patterning of the forebrain and midface, arises ~1 in 250 conceptions. It is associated with predisposing mutations in the Nodal and Hedgehog (HH) pathways, with penetrance and expressivity graded by genetic and environmental modifiers, via poorly understood mechanisms. CDON is a multifunctional co-receptor, including for the HH pathway. In mice, Cdon mutation synergiz...

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Literature Corpus work: 46dbc661-237f-54c8-8c8e-d587651a472e
DOI: 10.1101/2020.04.30.070870

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