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Article

Cdon mutation and fetal alcohol converge on Nodal signaling in a mouse model of holoprosencephaly.

eLife - 2 Sept 2020

Hong Mingi, Christ Annabel, Christa Anna, Willnow Thomas E, Krauss Robert S

Abstract excerpt

Holoprosencephaly (HPE), a defect in midline patterning of the forebrain and midface, arises ~1 in 250 conceptions. It is associated with predisposing mutations in the Nodal and Hedgehog (HH) pathways, with penetrance and expressivity graded by genetic and environmental modifiers, via poorly understood mechanisms. CDON is a multifunctional co-receptor, including for the HH pathway. In mice, Cdon mutation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32876567
DOI: 10.7554/eLife.60351
PMCID: PMC7467722

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Cdon mutation and fetal alcohol converge on Nodal signaling in a mouse model of holoprosencephaly.PMID 32876567Read ↗

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