Article

Gene-environment interactions characterized by single embryo transcriptomics

2019-10-15

Abstract excerpt

<h4> A bstract </h4> Gene-environment interactions are likely to underlie most human birth defects. The most common environmental contributor to birth defects is likely prenatal alcohol exposure. Fetal Alcohol Spectrum Disorders (FASD) describes the full range of defects that result from prenatal alcohol exposure. Gene-ethanol interactions underlie susceptibility to FASD but we lack a mechanistic understanding...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dd54f82f-0e9f-556c-98a8-5b6eaca12479
DOI: 10.1101/805556

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gene-environment interactions characterized by single embryo transcriptomicsDOI 10.1101/805556Read

Exposure to ethanol leads to midfacial hypoplasia in a zebrafish model of FASD via indirect interactions with the Shh pathwaySemantic proximity Read

A screen of zebrafish mutants identifies ethanol-sensitive genetic loci.Semantic proximity Read

Embryonic ethanol exposure alters expression of sox2 and other early transcripts in zebrafish, producing gastrulation defectsSemantic proximity Read

Mutations in the Bone Morphogenetic Protein signaling pathway sensitize zebrafish and humans to ethanol-induced jaw malformationsSemantic proximity Read

Bone Morphogenetic Protein signaling pathway – ethanol interactions disrupt palate formation independent of <i>gata3</i>Semantic proximity Read

<i>Cdon</i> mutation and fetal alcohol converge on Nodal signaling in a mouse model of holoprosencephalySemantic proximity Read

Pdgfra protects against ethanol-induced craniofacial defects in a zebrafish model of FASD.Semantic proximity Read

Gene–environment interactions in development and diseaseSemantic proximity Read

Fishing for Fetal Alcohol Spectrum Disorders: Zebrafish as a Model for Ethanol TeratogenesisSemantic proximity Read

Cdon mutation and fetal alcohol converge on Nodal signaling in a mouse model of holoprosencephaly.Semantic proximity Read

Review and gap analysis: molecular pathways leading to fetal alcohol spectrum disordersSemantic proximity Read

Ethanol exposure model in zebrafish causes phenotypic, behavioral and gene expression changes that mimic Fetal Alcohol Spectrum Disorders in human birth cohortsSemantic proximity Read