Article

Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum

2019-01-21

Abstract excerpt

The clinical syndromes of frontotemporal dementia are clinically and neuropathologically heterogeneous, but processes such as neuroinflammation may be common across the disease spectrum. We investigated how neuroinflammation relates to the aggregation of Tau and TDP-43 in frontotemporal dementia, and to the heterogeneity of clinical disease. We used positron emission tomography in vivo with (a) [ 11 C]PK-11195,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 46d017da-3440-5507-9990-f026116d32ec
DOI: 10.1101/525642

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrumDOI 10.1101/525642Read

<i>In vivo</i> PET imaging of neuroinflammation in familial frontotemporal dementiaSemantic proximity Read

Positron emission tomography in vivo characterisation of the pathology of frontotemporal dementiaSemantic proximity Read

Neuroinflammation in Lewy body dementia.Semantic proximity Read

Peripheral inflammatory markers relate to central inflammation and survival in syndromes associated with frontotemporal lobar degenerationSemantic proximity Read

Transcriptomic signatures of Aβ- and tau-induced neuronal dysfunction reveal inflammatory processes at the core of Alzheimer’s disease pathophysiologySemantic proximity Read

In vivo molecular imaging of neuroinflammation in Alzheimer's diseaseSemantic proximity Read

The role of monocytes and macrophages in the progression of Alzheimer’s diseaseSemantic proximity Read

Alzheimer<sup>’</sup>s-associated inflammatory alterations mediate tau-associated neurodegeneration in limbic and temporal regions across clinical variants of Alzheimer<sup>’</sup>s diseaseSemantic proximity Read

In vivo evidence for pre‐symptomatic neuroinflammation in a MAPT mutation carrierSemantic proximity Read

Neuroimaging of Inflammation in Memory and Related Other Disorders (NIMROD) study protocol: a deep phenotyping cohort study of the role of brain inflammation in dementia, depression and other neurological illnesses.Semantic proximity Read

Changes in glial cell phenotypes precede overt neurofibrillary tangle formation, correlate with markers of cortical cell damage, and predict cognitive status of individuals at Braak III-IV stages.Semantic proximity Read

Imaging tau burden in dementia with Lewy bodies using [18F]-AV1451 positron emission tomography.Semantic proximity Read