Article

Estrogens protect bone mass by inhibiting NAD <sup>+</sup> metabolism in osteoclasts

2025-07-16

Abstract excerpt

Estrogens protect against bone loss by reducing osteoclast number and bone resorption, primarily via direct actions on osteoclast precursors. In these cells, estrogens attenuate RANKL-induced stimulation of mitochondrial complex I, which is crucial for ATP generation through NADH oxidation. NAD + promotes redox reactions and activates NAD + -dependent enzymes, including the mitochondrial deacetylase SIRT3. Howev...

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Identifiers and source

Literature Corpus work: 46cf59db-69d4-5471-a22a-c433287c5a65
DOI: 10.1101/2025.07.11.664289

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