Article

mafsmith: a Rust reimplementation of vcf2maf

2026-05-15

Abstract excerpt

The Mutation Annotation Format (MAF) is a standard interchange format for somatic variant data in tumor genomics. Converting variant call format (VCF) files to MAF requires functional annotation (through tools such as the Ensembl Variant Effect Predictor) and complex allele normalisation and field-mapping logic. The gold-standard implementation, vcf2maf, is written in Perl and could be made more computationally ef...

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Literature Corpus work: 4668dbee-2b9d-52e7-b519-195af733f2d0
DOI: 10.64898/2026.05.12.724685

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