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Article

Stage 1 Plus: A phenotype-based framework for rational polytherapy in status epilepticus.

Epilepsia - 1 Sept 2026

Magro Giuseppe

Abstract excerpt

Current guidelines for status epilepticus (SE) prioritize treatment with a benzodiazepine (BDZ), followed, if seizures continue, by sequential stepwise therapy. Yet this pragmatic framework does not fully capture the biological heterogeneity apparent at first clinical evaluation. Some patients are treatment-naive but may already be at increased risk of early BDZ failure, because duration, semiology, etiology, or...

Read the complete abstract on PubMed

Topics

Status Epilepticus
Humans
Anticonvulsants
Phenotype
Benzodiazepines
Drug Therapy, Combination

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42313378
DOI: 10.1002/epi.70355

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