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Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a Mendelian randomization analysis using outcomes in first-degree relatives

2020-11-12

Abstract excerpt

<h4>Background</h4> Apolipoprotein B (apoB) is emerging as the lipoprotein entity that is critical for the role that lipoprotein lipids play in the aetiology of coronary heart disease (CHD). In this study, we explored effects of genetically-predicted apoB on endpoints in first-degree relatives. <h4>Methods</h4> Univariable Mendelian randomization (MR) used a weighted genetic instrument (229 SNPs) for apoB. For end...

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Literature Corpus work
46514f48-c91f-5206-bc97-8e44a37c6e8d
DOI
10.1101/2020.11.09.20227801
Open publication

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Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a Mendelian randomization analysis using outcomes in first-degree relativesDOI 10.1101/2020.11.09.20227801
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