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Article

Mendelian randomization reveals apolipoprotein B shortens healthspan and possibly increases risk for Alzheimer's disease.

Communications biology - 24 Feb 2024

Martin Leah, Boutwell Brian B, Messerlian Carmen, Adams Charleen D

Abstract excerpt

Apolipoprotein B-100 (APOB) is a component of fat- and cholesterol-transporting molecules in the bloodstream. It is the main lipoprotein in low-density lipoprotein cholesterol (LDL) and has been implicated in conditions that end healthspan (the interval between birth and onset of chronic disease). However, APOB's direct relationship with healthspan remains uncertain. With Mendelian randomization, we show that...

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Identifiers

PMID: 38402277
DOI: 10.1038/s42003-024-05887-2
PMCID: PMC10894226

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