Article

AI-guided use of balanced PPARα/γ dual agonist finetunes macrophage responses in inflammatory bowel disease

2021-03-19

Abstract excerpt

<title>Abstract</title> <p>A computational platform, the Boolean network explorer (BoNE), has recently been developed to infuse AI-enhanced precision into drug discovery; it enables querying and navigating invariant Boolean Implication Networks of disease maps for prioritizing high-value targets. Here we used BoNE to query an Inflammatory Bowel Disease (IBD)-map and prioritize two nuclear receptors, PPARα/γ. Bala...

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Literature Corpus work: 459c80a2-e279-5b20-bf0c-48a9467107ad
DOI: 10.21203/rs.3.rs-243294/v1

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