Article

Artificial Intelligence-rationalized balanced PPARα/γ dual agonism resets the dysregulated macrophage processes in inflammatory bowel disease

2021-07-19

Abstract excerpt

<h4>ABSTRACT</h4> A computational platform, the Boolean network explorer ( BoNE ), has recently been developed to infuse AI-enhanced precision into drug discovery; it enables querying and navigating invariant Boolean Implication Networks of disease maps for prioritizing high-value targets. Here we used BoNE to query an Inflammatory Bowel Disease (IBD)-map and prioritize a therapeutic strategy that involves dual...

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Literature Corpus work: 8ef3008f-86a0-56fd-b795-532ca097a6f1
DOI: 10.1101/2021.07.18.452807

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