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Article

Dissociable Thalamocortical Circuit Disruptions During Contextual Fear Renewal in PTSD

2026-06-17

Abstract excerpt

<h4>Objective</h4> Post-traumatic stress disorder (PTSD) is marked by impaired contextual modulation of fear, leaving patients vulnerable to symptom return after extinction-based therapy. The thalamus is theorized to coordinate hippocampal-prefrontal circuits during contextual updating. Yet, its role in PTSD remains uncharacterized. We examined the contribution of the medial mediodorsal thalamus (MDm) to extincti...

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Literature Corpus work
456bb8ab-9741-5489-986c-6ffb92415983
DOI
10.64898/2026.06.15.26355743
Open publication

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Dissociable Thalamocortical Circuit Disruptions During Contextual Fear Renewal in PTSDDOI 10.64898/2026.06.15.26355743
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