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Article

Identification of an intrusive-hypervigilant phenotype of posttraumatic stress symptoms with unique stress peptide and amygdala functional connectivity profiles.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2026

Clancy Kevin J, Ravichandran Caitlin, Jobson Sydney A, May Victor, Hammack Sayamwong E, Carlezon William A, Ressler Kerry J, Rauch Scott L, Rosso Isabelle M

Abstract excerpt

Posttraumatic stress disorder (PTSD) is a highly heterogeneous psychiatric disorder, complicating efforts to identify consistent biological markers and develop targeted treatments for individuals exposed to trauma. Recent research has identified a distinct intrusive-hypervigilant (IH) phenotype, which is characterized by heightened intrusive reexperiencing and hypervigilance symptoms along with elevated levels of...

Read the complete abstract on PubMed

Topics

Humans
Stress Disorders, Post-Traumatic
Amygdala
Magnetic Resonance Imaging
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Phenotype

Adult

Pituitary Adenylate Cyclase-Activating Polypeptide

Young Adult

Neural Pathways

Source

Open in PubMed Open full text

Identifiers

PMID: 41951830
DOI: 10.1038/s41386-026-02396-0
PMCID: PMC13598154

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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