Article

mRNA Degradation Rates Are Coupled to Metabolic Status in Mycobacteria

2019-04-01

Abstract excerpt

<h4>ABSTRACT</h4> The success of Mycobacterium tuberculosis (Mtb) as a human pathogen is due in part to its ability to survive stress conditions, such as hypoxia or nutrient deprivation, by entering non-growing states. In these low-metabolic states, Mtb can tolerate antibiotics and develop genetically encoded antibiotic resistance, making its metabolic adaptation to stress crucial for survival. Numerous bacteria...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 456b8942-ee52-5383-a0d7-70ce7d64db43
DOI: 10.1101/595199

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

mRNA Degradation Rates Are Coupled to Metabolic Status in MycobacteriaDOI 10.1101/595199Read

Global analysis of mRNA stability in Mycobacterium tuberculosisSemantic proximity Read

Noise in a Metabolic Pathway Leads to Persister Formation in Mycobacterium tuberculosisSemantic proximity Read

Mechanisms of Antibiotic Tolerance in Mycobacterium avium Complex: Lessons From Related MycobacteriaSemantic proximity Read

The dormancy regulator DosR controls ribosome stability in hypoxic mycobacteria.Semantic proximity Read

Defining the transcriptional and post-transcriptional landscapes of <i>Mycobacterium smegmatis</i> in aerobic growth and oxygen limitationSemantic proximity Read

Defining the Transcriptional and Post-transcriptional Landscapes of Mycobacterium smegmatis in Aerobic Growth and HypoxiaSemantic proximity Read

Translational regulation in mycobacteria and its implications for pathogenicitySemantic proximity Read

Metabolic regulation of mycobacterial growth and antibiotic sensitivity.Semantic proximity Read

Small RNA Mcr11 regulates genes involved in the central metabolism of <i>Mycobacterium tuberculosis</i> and requires 3’ sequence along with the transcription factor AbmR for stable expressionSemantic proximity Read

Gene Regulatory Mechanism of Mycobacterium Tuberculosis during DormancySemantic proximity Read

Incomplete transcripts dominate the <i>Mycobacterium tuberculosis</i> transcriptomeSemantic proximity Read

Dormant non-culturable Mycobacterium tuberculosis retains stable low-abundant mRNA.Semantic proximity Read