Article

A randomized, double-blind, placebo-controlled phase 2b trial using the novel predictive genetic biomarker DGM4 for liafensine in treatment-resistant depression

2024-12-13

Abstract excerpt

<title>Abstract</title> <p>Prior clinical trials evaluating liafensine for treatment-resistant depression (TRD) in unselected patients did not demonstrate benefit vs controls. A novel pharmacogenomic biomarker, DGM4, was discovered as a predictor of liafensine’s efficacy and assessed in this new prospective clinical trial. In this biomarker-guided, randomized, double-blind, placebo-controlled Phase 2b trial, 189...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 455f6293-00e3-5b56-8432-ccd5e7a4bdee
DOI: 10.21203/rs.3.rs-5569323/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A randomized, double-blind, placebo-controlled phase 2b trial using the novel predictive genetic biomarker DGM4 for liafensine in treatment-resistant depressionDOI 10.21203/rs.3.rs-5569323/v1Read

Discovery of a novel pharmacogenomic biomarker on ANK3gene for liafensine, a triple reuptake inhibitor for treatment-resistant depressionSemantic proximity Read

The MAKE Biomarker Discovery for Enhancing anTidepressant Treatment Effect and Response Study: Design and MethodologySemantic proximity Read

Role of the Pharmacogenomics in the Treatment-Resistant Depression: A Literature ReviewSemantic proximity Read

Depression and Pharmacogenetics.Semantic proximity Read

A prospective, randomized, double-blind study assessing the clinical impact of integrated pharmacogenomic testing for major depressive disorder.Semantic proximity Read

Individualized Treatment Strategy for Depressive Disorder.Semantic proximity Read

Transcriptome-wide association study of treatment-resistant depression and depression subtypes for drug repurposingSemantic proximity Read

Phenotype-by-phenome-wide association study of treatment resistant depressionSemantic proximity Read

Genetic Markers for Later Remission in Response to Early Improvement of Antidepressants.Semantic proximity Read

Translating GWAS Findings Into Therapies For Depression And Anxiety Disorders: Drug Repositioning Using Gene-Set Analyses Reveals Enrichment Of Psychiatric Drug ClassesSemantic proximity Read

International Union of Basic and Clinical Pharmacology CIV: The Neurobiology of Treatment-resistant Depression: From Antidepressant Classifications to Novel Pharmacological Targets.Semantic proximity Read

Molecular Signatures of Lithium Treatment: Current KnowledgeSemantic proximity Read