Back to search

Article

Fisetin extends lifespan in a murine model of recessive dystrophic epidermolysis bullosa

2024-11-24

Abstract excerpt

Recessive Dystrophic Epidermolysis Bullosa (RDEB) is a rare genodermatosis characterized clinically by extensive inflammation, cutaneous destruction, and fibrosis that demonstrates properties similar to rapid skin aging. As tissue ages, it accumulates cellular damage and exhaustion leading to a state of senescence. Cellular senescence is an aging or disease-related phenomenon of stable exit from the cell cycle tha...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4551ecc2-6a0f-5dc4-8e28-d6fa8aa90e13
DOI
10.1101/2024.11.23.625023
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Fisetin extends lifespan in a murine model of recessive dystrophic epidermolysis bullosaDOI 10.1101/2024.11.23.625023
Cellular Senescence in Human Skin Aging: Leveraging SenotherapeuticsSemantic proximity
Cellular senescence in skin‐related research: Targeted signaling pathways and naturally occurring therapeutic agentsSemantic proximity
Pathology of Mouse Models of Accelerated Aging.Semantic proximity
Targeting Dermal Fibroblast Senescence: From Cellular Plasticity to Anti-Aging TherapiesSemantic proximity
Skin senescence—from basic research to clinical practiceSemantic proximity
Novel Senolytic Ingredient, Camellia sinensis Root Extract, Ameliorates Skin Aging-Associated PhenotypesSemantic proximity
Skin senescence: mechanisms and impact on whole-body aging.Semantic proximity
Decorin counteracts disease progression in mice with recessive dystrophic epidermolysis bullosaSemantic proximity
Senescent Fibroblast–Derived GDF15 Induces Skin PigmentationSemantic proximity
Senescent cell transplantation into the skin induces age‐related peripheral dysfunction and cognitive declineSemantic proximity
Strategies to make human skin models based on cellular senescence for ageing researchSemantic proximity
The role of sirtuins in dermal fibroblast functionSemantic proximity
Select a neighboring publication to make it the new centre.