Article

The Genetic Basis for the Cooperative Bioactivation of Plant Lignans by a Human Gut Bacterial Consortium

2018-06-27

Abstract excerpt

Plant-derived lignans, consumed daily by most individuals, are inversely associated with breast cancer; however, their bioactivity is only exerted following gut bacterial conversion to enterolignans. Here, we dissect a four-species bacterial consortium sufficient for all four chemical reactions in this pathway. Comparative genomics and heterologous expression experiments identified the first enzyme in the pathway....

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Identifiers and source

Literature Corpus work: 454694d7-1462-5471-bb0e-cff2e3bf6825
DOI: 10.1101/357640

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