Article

Bootstrat: Population Informed Bootstrapping for Rare Variant Tests

2016-08-11

Abstract excerpt

Recent advances in genotyping and sequencing technologies have made detecting rare variants in large cohorts possible. Various analytic methods for associating disease to rare variants have been proposed, including burden tests, C-alpha and SKAT. Most of these methods, however, assume that samples come from a homogeneous population, which is not realistic for analyses of large samples. Not correcting for populatio...

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Literature Corpus work: 44f4ff80-3263-5560-add2-52f6592d4b8a
DOI: 10.1101/068999

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