Reovirus Reassortants Reveal Context-Dependent Oncolytic Phenotypes Across Epithelial Cancer Cell Lines.

doi:10.1177/08828245261464827

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Article

Reovirus Reassortants Reveal Context-Dependent Oncolytic Phenotypes Across Epithelial Cancer Cell Lines.

Viral immunology - 1 Sept 2026

Hutchinson J Ryder, Carter Owen M, Dagli Charlotte V, Rivera-Serrano Efraín E

Abstract excerpt

Mammalian reoviruses are promising oncolytic agents, but most preclinical and clinical work has focused on the type 3 Dearing (T3D) prototype, potentially underestimating the therapeutic relevance of broader reovirus genetic diversity. Because reoviruses possess a segmented double-stranded RNA genome, reassortment can generate progeny with novel combinations of traits influencing infectivity, replication, and...

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PMID: 42376862
DOI: 10.1177/08828245261464827

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