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Article

Sex differences in genetic modifiers of traumatic brain injury and late-life cognitive decline: the Cache County study.

The journals of gerontology. Series A, Biological sciences and medical sciences - 7 Apr 2026

Drewel Mikaela A, Schwartz Sarah, Rattinger Gail B, Buhusi Mona, Tschanz JoAnn T

Abstract excerpt

BACKGROUND: Traumatic brain injury (TBI) is a well-recognized risk factor for late-life cognitive decline. However, few studies have examined individual differences in sex and genetics, which may modify risk. We examined sex differences in gene-TBI interactions for dementia risk genes apolipoprotein E (APOE) and selected brain-derived neurotrophic factor (BDNF) single-nucleotide polymorphisms (SNPs) in predicting...

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Identifiers

PMID: 41559920
DOI: 10.1093/gerona/glag011

Genes

APOE
BDNF

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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