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The dietary ellagitannin metabolite urolithin A is produced by a molybdenum-dependent dehydroxylase encoded by prevalent human gut <i>Enterocloster</i> spp

2024-02-09

Abstract excerpt

Urolithin A (uroA) is a polyphenol derived from the multi-step metabolism of dietary ellagitannins by the human gut microbiota that can affect host health by stimulating mitophagy. Most individuals harbor a microbiota capable of uroA production; however, the mechanisms underlying the dehydroxylation of its catechol-containing dietary precursor (uroC) are unknown. Here, we use a combination of untargeted bacterial...

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Identifiers and source

Literature Corpus work
3858f4b4-d8c4-5557-b7f3-d844a6545634
DOI
10.1101/2024.02.08.579493
Open publication

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