Article

Deep Modeling of Gain-of-Function Mutations on Androgen Receptor

2025-01-24

Abstract excerpt

The efficiency of Androgen Receptor (AR) pathway inhibitors for prostate cancer (PCa) is on decline due to resistance mechanisms including the occurrence of gain-of-function mutations on human androgen receptor (AR). Hence, understanding and predicting such mutations is crucial for developing effective PCa treatment strategies. Leveraging accumulated data on clinically relevant AR mutants with recent advances in d...

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Literature Corpus work: 43cb0bb6-2eff-541e-8a72-00aed6eb4f1d
DOI: 10.1101/2025.01.20.633961

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