Article
DeepAlloDriver: a deep learning-based strategy to predict cancer driver mutations.
Nucleic acids research - 5 Jul 2023
Song Qianqian, Li Mingyu, Li Qian, Lu Xun, Song Kun, Zhang Ziliang, Wei Jiale, Zhang Liang, Wei Jiacheng, Ye Youqiong, Zha Jinyin, Zhang Qiufen, Gao Qiang, Long Jiang, Liu Xinyi, Lu Xuefeng, Zhang Jian
Abstract excerpt
Driver mutations can contribute to the initial processes of cancer, and their identification is crucial for understanding tumorigenesis as well as for molecular drug discovery and development. Allostery regulates protein function away from the functional regions at an allosteric site. In addition to the known effects of mutations around functional sites, mutations at allosteric sites have been associated with...
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