Article
In silico comparison between the mutated and wild-type androgen receptors and their influence on the selection of optimum androgenic receptor blockers for the treatment of prostate cancer.
F1000Research - 1 Jan 2022
Al-Zobaidy Mohammed J, Akeel Al-Hussaniy Hany, S Al-Tameemi Zahraa
Abstract excerpt
Background: Prostate cancer is a disease that occurs in men aged more than 50 years. In Iraq, 8.89 men per 100,000 population suffer from prostate cancer, with the incidence being 14,016 cases and mortality being 6,367 cases. Despite advances in treatment against prostate cancer, it can become resistant to drugs. Therefore, the aim of current study was to search and identify binding sites for the repositioning of...
Topics
- Male
- Receptors, Androgen
- Humans
- Prostatic Neoplasms
- Androgen Receptor Antagonists
- Mutation
- Molecular Docking Simulation
- Computer Simulation
- Benzamides
- Nitriles