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The Estrogen Receptor-Related Orphan Receptors (ERRs) Regulate Autophagy through TFEB

2023-03-02

Abstract excerpt

Autophagy is an essential self-degradative and recycling mechanism that maintains cellular homeostasis. Estrogen receptor-related orphan receptors (ERRs) play fundamental role in regulation of cardiac metabolism and function. Previously, we showed that ERR agonists improve cardiac function in models of heart failure and induce autophagy in cardiomyocytes. Here, we characterized a mechanism by which ERRs induce aut...

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Literature Corpus work
43b3385a-2848-50e1-a908-daa095c9bfef
DOI
10.1101/2023.03.02.530836
Open publication

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