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Article

A viewpoint on the genetic determinants of generalised pustular psoriasis.

Experimental dermatology - 1 Aug 2023

Capon Francesca

Abstract excerpt

Generalised pustular psoriasis (GPP) is a rare and severe neutrophilic skin disorder, manifesting with acute episodes of pustulation and systemic upset. The discovery of recessive IL36RN mutations associated with GPP has transformed our understanding of disease drivers, paving the way for the development of targeted anti-IL36 therapeutics. In the light of these remarkable successes, this viewpoint reviews the...

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PMID: 36645252
DOI: 10.1111/exd.14746

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