Article

Cell-resolved transcriptomics separates the components of a pathway- wide PI3K–AKT response in dilated cardiomyopathy: the AKT1 change localizes to cardiomyocytes, the PIK3CA change peaks in fibroblasts

2026-08-18

Abstract excerpt

<title>Abstract</title> <p> Network pharmacology nominates targets but cannot show that they are active in the relevant cell or linked to disease. Using Yangxin Decoction in dilated cardiomyopathy (DCM) and viral myocarditis, we tested which nominated PI3K–AKT candidates survive independent functional-genomic evidence. Most did not. A direct-evidence intersection returned 61 shared genes, but across four bulk ca...

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Literature Corpus work: 43a0bcfa-ab72-54d5-988a-252e6d98b37e
DOI: 10.21203/rs.3.rs-10584049/v1

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Cell-resolved transcriptomics separates the components of a pathway- wide PI3K–AKT response in dilated cardiomyopathy: the AKT1 change localizes to cardiomyocytes, the PIK3CA change peaks in fibroblastsDOI 10.21203/rs.3.rs-10584049/v1Read

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