Genetic architecture of 67 oral diseases and their links to systemic diseases

Abstract excerpt

Oral and craniofacial diseases are common, yet their genetic basis and links to systemic health are incompletely understood. We performed genome-wide association analyses of 67 oral phenotypes in 500,348 FinnGen participants, identifying 105 genome-wide significant loci, including 47 previously unreported associations. Fine-mapping revealed 14 coding variants, such as a missense variant in USP31 for caries and in...

Topics

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• Alleles
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• HLA-DQ alpha-Chains
• HLA-DQ beta-Chains
• Mouth Diseases
• Phenotype
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

436bc596-85a3-5597-81cb-653ffeb24472

DOI

10.1101/2025.10.16.25338184