Article
Oral and non-oral lichen planus show genetic heterogeneity and differential risk for autoimmune disease and oral cancer.
American journal of human genetics - 6 Jun 2024
Reeve Mary Pat, Vehviläinen Mari, Luo Shuang, Ritari Jarmo, Karjalainen Juha, Gracia-Tabuenca Javier, Mehtonen Juha, Padmanabhuni Shanmukha Sampath, Kolosov Nikita, Artomov Mykyta, Siirtola Harri, Olilla Hanna M, Graham Daniel, Partanen Jukka, Xavier Ramnik J, Daly Mark J, Ripatti Samuli, Salo Tuula, Siponen Maria
Abstract excerpt
Lichen planus (LP) is a T-cell-mediated inflammatory disease affecting squamous epithelia in many parts of the body, most often the skin and oral mucosa. Cutaneous LP is usually transient and oral LP (OLP) is most often chronic, so we performed a large-scale genetic and epidemiological study of LP to address whether the oral and non-oral subgroups have shared or distinct underlying pathologies and their overlap...
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