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Article

Genetic architecture of 67 oral diseases and their links to systemic diseases.

HGG advances - 9 Jul 2026

Karppinen Kirika, Ollila Hanna M, Batool Kanwal, Abner Erik, Rice David P, Palotie Aarno, Palotie Tuula, Ripatti Samuli, Mars Nina, Strausz Satu

Abstract excerpt

Oral and craniofacial diseases are common, yet their genetic basis and links to systemic health are incompletely understood. We performed genome-wide association analyses of 67 oral phenotypes in 500,348 FinnGen participants, identifying 102 genome-wide significant loci, including 45 previously unreported associations. 48 loci remained significant after category-level Bonferroni correction. Fine-mapping revealed...

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Identifiers

PMID: 42310951
DOI: 10.1016/j.xhgg.2026.100633
PMCID: PMC13343153

Genes

GPNMB
MANBA
USP31

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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