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Article

The over-pruning hypothesis of autism.

Developmental science - 1 Mar 2016

Thomas Michael S C, Davis Rachael, Karmiloff-Smith Annette, Knowland Victoria C P, Charman Tony

Abstract excerpt

This article outlines the over-pruning hypothesis of autism. The hypothesis originates in a neurocomputational model of the regressive sub-type (Thomas, Knowland & Karmiloff-Smith, 2011a, 2011b). Here we develop a more general version of the over-pruning hypothesis to address heterogeneity in the timing of manifestation of ASD, including new computer simulations which reconcile the different observed...

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Identifiers

PMID: 25845529
DOI: 10.1111/desc.12303

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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