Article

Unveiling COL4A1 as a Key Driver Gene in scleroderma: Insights from Single-Cell and Bulk RNA Sequencing

2025-10-10

Abstract excerpt

<title>Abstract</title> <p>Keloids and systemic sclerosis (SSc) are fibrotic disorders characterized by abnormal wound healing, leading to excessive collagen deposition and tissue fibrosis. The inflammatory and immune responses play critical roles in their pathogenesis, yet the molecular mechanisms remain elusive. We utilized high-throughput RNA sequencing (GSE130955) and single-cell RNA sequencing (GSE163973) da...

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Literature Corpus work: 4357cbe2-3113-54ea-9ed5-49c9c488b6b8
DOI: 10.21203/rs.3.rs-7376155/v1

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