Article
Integrative Multiomics and Drug Sensitivity Profiling Reveal Potential Biomarkers and Therapeutic Strategies in Pediatric Solid Tumors.
Cancer research - 2 Feb 2026
ElHarouni Dina, Hernansaiz-Ballesteros Rosa, Peterziel Heike, Balasubramanian Gnana Prakash, Previti Christopher, Schramm Kathrin, Blattner-Johnson Mirjam, Kabbe Rolf, Jones Barbara C, Oppermann Sina, Jones David T W, Pfister Stefan M, Witt Olaf, Saez-Rodriguez Julio, Oehme Ina, Jäger Natalie, Schlesner Matthias
Abstract excerpt
Cure rates for childhood malignancies using established therapy protocols have increased to an average of 80% but have reached a plateau. Moreover, survival rates are particularly low for some pediatric tumors-such as high-risk group 3 medulloblastomas, osteosarcomas, Ewing sarcomas, high-risk neuroblastomas, and high-grade gliomas-and dismal for patients with relapsed malignancies. A functional drug response...
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