Article

Circulating Microbial DNA as a Potential Cancer Biomarker: Technical Challenges and Controlled Evaluation

2026-08-20

Abstract excerpt

Abstract Background. Circulating microbial DNA (cmDNA) has been proposed as a non-invasive cancer biomarker, but most evidence comes from cancer-sequencing datasets not designed for microbial analysis and lacking contamination controls. Whether reported signatures reflect biology or artifact is unclear in low-biomass specimens, where standard taxonomic pipelines are prone to systematic error. Methods. In a tightly...

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Literature Corpus work: 42a2fd75-194b-5ea0-a594-2cc7c7850870
DOI: 10.64898/2026.08.17.745053

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