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Detection of ctDNA in plasma of patients with clinically localised prostate cancer is associated with rapid disease progression

17 Aug 2020

Abstract excerpt

BACKGROUND: DNA originating from degenerate tumour cells can be detected in the circulation in many tumour types, where it can be used as a marker of disease burden as well as to monitor treatment response. Although circulating tumour DNA (ctDNA) measurement has prognostic/predictive value in metastatic prostate cancer, its utility in localised disease is unknown. METHODS: We performed whole-genome sequencing of...

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PMID: 32807235
DOI: 10.1186/s13073-020-00770-1

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