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Structure of mycobacterial ergothioneine-biosynthesis C-S lyase EgtE

9 Dec 2023

Abstract excerpt

L-ergothioneine is widely distributed among various microbes to regulate their physiology and pathogenicity within complex environments. One of the key steps in the ergothioneine-biosynthesis pathway, the C-S bond cleavage reaction, uses the pyridoxal 5'-phosphate dependent C-S lyase to produce the final product L-ergothioneine. Here, we present the crystallographic structure of the ergothioneine-biosynthesis C-S...

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PMID: 38072054
DOI: 10.1016/j.jbc.2023.105539

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