Nasopharyngeal infection by <i>Streptococcus pyogenes</i> requires superantigen-responsive Vβ-specific T cells

Abstract excerpt

Significance Superantigen toxins were defined over 25 years ago for their ability to activate T cells in a T-cell receptor β-chain variable domain-dependent manner. This “Vβ-specific” T-cell activation is the hallmark feature of the superantigen, and although these toxins can mediate dangerous human disease such as toxic shock syndrome, mechanisms that explain why bacteria produce superantigens have remained...

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