Article

The Synergism Between DHODH Inhibitors and Dipyridamole Leads to Metabolic Lethality in Acute Myeloid Leukemia

2020-10-10

Abstract excerpt

<h4>Background</h4> Dihydroorotate Dehydrogenase (DHODH) is a key enzyme of the de novo pyrimidine biosynthesis, whose inhibition was recently found to induce differentiation and apoptosis in acute myeloid leukemia (AML). DHODH inhibitors were previously investigated in solid tumors, where they showed promising antiproliferative activity, both in vitro and in vivo . However, their effectiveness was not confirm...

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Literature Corpus work: 420ad39a-aadd-5da9-a532-60be743aceec
DOI: 10.1101/2020.10.10.334631

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