Article

Significant Upregulation of Alzheimer's β‐Amyloid Levels in a Living System Induced by Extracellular Elastin Polypeptides

2019-10-14

Abstract excerpt

Abstract Alzheimer's disease (AD) is a neurodegenerative disorder and the primary cause of age‐related dementia. The etiology of AD is complex and has not been completely elucidated. Herein, we report that treatment with elastin‐like polypeptides (ELPs), a component of the brain extracellular matrix (ECM), significantly increased the levels of AD‐related amyloid‐β peptides (Aβ) both in vitro and in vivo. Regarding...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 41fffb9b-f4b0-528b-a3dc-065786792e2b
DOI: 10.1002/ange.201912399

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 9 closest

Significant Upregulation of Alzheimer's β‐Amyloid Levels in a Living System Induced by Extracellular Elastin PolypeptidesDOI 10.1002/ange.201912399Read

Significant Upregulation of Alzheimer's β‐Amyloid Levels in a Living System Induced by Extracellular Elastin PolypeptidesSemantic proximity Read

Extracellular Matrix Proteins Involved in Alzheimer's DiseaseSemantic proximity Read

Amyloid β-protein oligomers and Alzheimer’s diseaseSemantic proximity Read

MR elastography detection of early viscoelastic response of the murine hippocampus to amyloid β accumulation and neuronal cell loss due to Alzheimer's disease.Semantic proximity Read

The short-term improvements of enriched environment in behaviors and pathological changes of APP/PS1 mice via regulating cytokines.Semantic proximity Read

Effects of amyloid-β-mimicking peptide hydrogel matrix on neuronal progenitor cell phenotype.Semantic proximity Read

Intraperitoneal injection of the pancreatic peptide amylin potently reduces behavioral impairment and brain amyloid pathology in murine models of Alzheimer's disease.Semantic proximity Read

Intervertebral disc impairments in a mouse model of Alzheimer’s DiseaseSemantic proximity Read

Moderate environmental enrichment mitigates tauopathy in a neurofibrillary tangle mouse model.Semantic proximity Read