Article

MCF-7 breast cancer cell line PacBio generated transcriptome has ~300 novel transcribed regions, un-annotated in both RefSeq and GENCODE, and absent in the liver, heart and brain transcriptomes

2017-01-17

Abstract excerpt

Illuminating the ‘dark’ regions of the human genome remains an ongoing effort, a decade and a half after the human genome was sequenced - RefSeq and GENCODE being two of the major annotation databases. Pacific Biosciences (PacBio) has provided open access to the transcriptome of MCF-7, a breast cancer cell line that has provided significant therapeutic advancement in breast cancer research since the 1970s. PacBio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 41c192c1-cfc3-5a4c-b0a2-8ac4ccb642da
DOI: 10.1101/100974

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MCF-7 breast cancer cell line PacBio generated transcriptome has ~300 novel transcribed regions, un-annotated in both RefSeq and GENCODE, and absent in the liver, heart and brain transcriptomesDOI 10.1101/100974Read

Shorter unreported sequences in a RACE-Seq study involving seven tissues confirms ∼150 novel transcripts identified in MCF-7 cell line PacBio transcriptome, leaving ∼100 non-redundant transcripts exclusive to the cancer cell lineSemantic proximity Read

Full-length mRNA sequencing uncovers a widespread coupling between transcription and mRNA processingSemantic proximity Read

Revealing missing isoforms encoded in the human genome by integrating genomics, transcriptomics and proteomics dataSemantic proximity Read

Illuminating the dark side of the human transcriptome with long read transcript sequencingSemantic proximity Read

At the dawn of the transcriptomic medicine.Semantic proximity Read

Cataloguing over-expressed genes in Epstein Barr Virus immortalized lymphoblastoid cell lines through consensus analysis of PacBio transcriptomes corroborates hypomethylation of chromosome 1Semantic proximity Read

Epigenomic, transcriptomic and proteomic characterizations of reference samplesSemantic proximity Read

A deep audit of the PeptideAtlas database uncovers evidence for unannotated coding genes and aberrant translationSemantic proximity Read

Two novel lncRNAs discovered in human mitochondrial DNA using PacBio full-length transcriptome dataSemantic proximity Read

Transcriptome Profiling of Epstein-Barr Virus Using Nanopore SequencingSemantic proximity Read

Illuminating the dark side of the human transcriptome with TAMA Iso-Seq analysisSemantic proximity Read

Long-read cDNA sequencing identifies functional pseudogenes in the human transcriptomeSemantic proximity Read