Article

Loss of function and structural variants in the <i>PRKRA</i> synaptic gene link mild cognitive impairment and tinnitus

2025-11-13

Abstract excerpt

The genetic basis underlying the co-occurrence of tinnitus and mild cognitive impairment (MCI) remains unknown. Adults with chronic tinnitus from a European cohort were classified into MCI (n=75) and non-MCI (n=201) groups, and rare variant distributions were assessed using gene burden analyses. Approximately one-fourth of individuals with chronic tinnitus exhibited MCI in their early fifties. Rare loss-of-functio...

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Literature Corpus work: 41871703-3031-54a2-8df5-f6bb20b1c5ad
DOI: 10.1101/2025.11.04.25339446

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