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Article

Clopidogrel preventive effect based on cytochrome P450 2C19 genotype in ischaemic stroke: protocol for multicentre observational study.

BMJ open - 5 Aug 2020

Song Tae-Jin, Kim Jinkwon, Han Sang Won, Kim Young Dae, Lee Jong Yun, Ahn Seong Hwan, Lee Hye Sun, Jung Yo Han, Lee Kyung-Yul

Abstract excerpt

INTRODUCTION: Clopidogrel is an antiplatelet agent that is widely used for the secondary prevention of cardiovascular and cerebrovascular events. The genotype of cytochrome P450 2C19 (CYP2C19) differentially affects the liver's metabolism of clopidogrel, which may influence the drug's response and efficacy for cardiovascular event prevention. In contrast to prior studies of patients with coronary artery diseases,...

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Brain Ischemia
Clopidogrel
Cytochrome P-450 CYP2C19
Ischemic Stroke
Multicenter Studies as Topic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Observational Studies as Topic

Platelet Aggregation Inhibitors

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Open in PubMed Open full text

Identifiers

PMID: 32759249
DOI: 10.1136/bmjopen-2020-038031
PMCID: PMC7409960

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