Article

Parkinson Disease Neuropathological Comorbidities: Prevalences from Younger-Old to Older-Old, With Comparison to Non-Demented, Non-Parkinsonian Subjects

2025-01-15

Abstract excerpt

Co-existing neuropathological comorbidities have been repeatedly reported to be extremely common in subjects dying with dementia due to Alzheimer disease. As these are likely to be additive to cognitive impairment, and may not be affected by molecularly-specific AD therapeutics, they may cause significant inter-individual response heterogeneity amongst subjects in AD clinical trials. Furthermore, while originally...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4155e563-bf9a-5b3d-a57b-189ef3bb39a3
DOI: 10.1101/2025.01.13.25319971

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Parkinson Disease Neuropathological Comorbidities: Prevalences from Younger-Old to Older-Old, With Comparison to Non-Demented, Non-Parkinsonian SubjectsDOI 10.1101/2025.01.13.25319971Read

Alzheimer’s Disease Neuropathological Comorbidities Are Common in the Younger-OldSemantic proximity Read

Prevalence of Concomitant Pathologies in Parkinson’s Disease: Implications for Prognosis, Diagnosis, and Insights into Common Pathogenic MechanismsSemantic proximity Read

Cognitive impairment in Parkinson's disease : impact and identification of comorbid disease mechanismsSemantic proximity Read

Are comorbidities compatible with a molecular pathological classification of neurodegenerative diseases?Semantic proximity Read

Neuropathology in genetic Parkinson's disease: a focused review of pathological and clinical findings.Semantic proximity Read

Comorbid neuropathological diagnoses in early vs late-onset Alzheimer’s diseaseSemantic proximity Read

APOE, thought disorder, and SPARE-AD predict cognitive decline in established Parkinson's disease.Semantic proximity Read

Modelling idiopathic Parkinson disease as a complex illness can inform incidence rate in healthy adults: the PR EDIGT score.Semantic proximity Read

Comorbidities in Early-Onset Sporadic versus Presenilin-1 Mutation-Associated Alzheimer’s Disease Dementia: Evidence for Dependency on Alzheimer’s Disease Neuropathological ChangesSemantic proximity Read

Overlap between neurodegenerative disordersSemantic proximity Read

Presence of cerebral amyloid modulates phenotype and pattern of neurodegeneration in early Parkinson's disease.Semantic proximity Read

Clinical trials in dementia with Lewy bodies: the evolving concept of co-pathologies, patient selection and biomarkers.Semantic proximity Read